Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes.
نویسندگان
چکیده
منابع مشابه
Evolutionary conservation of 5' upstream sequence of nine genes between human and great apes.
Nucleotide sequences of nine 5' upstream gene regions for human, chimpanzee, gorilla, and orangutan were determined. We estimated nucleotide differences (d) for each region between human and great apes. The overall d was 0.027 (ranged from 0.004 to 0.052). Rates of nucleotide substitution were estimated by using d and divergence times of human, chimpanzee, gorilla, and orangutan. The overall ra...
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چکیده ندارد.
Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions for HLA Class I Genes.
Polymorphisms located within the MHC have been linked to many disease outcomes by mechanisms not yet fully understood in most cases. Variants located within untranslated regions of HLA genes are involved in allele-specific expression and may therefore underlie some of these disease associations. We determined sequences extending nearly 2 kb upstream of the transcription start site for 68 allele...
متن کاملThe genomic organization of type I keratin genes in mice.
We isolated two new keratin cDNAs by screening a cDNA library constructed from poly(A)+ RNA of the dorsal and abdominal skin of C57BL/10J mice with a probe of human KRT14. Due to its high sequence homology to human keratin 17 cDNA, one full-length cDNA is most likely to be mouse keratin 17 (Krt1-17) cDNA. The other is the putative full-length cDNA of a novel type I keratin gene, designated Krt1...
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این تحقیق کوشیده است با انتخاب پنج رمان از میان آثار برگزیده، «چارلز دیکنز»، «جورج الیوت» و «توماس هاردی » و با رویکردی تطبیقی به بررسی درونمایه ی «ازدواج» در آثار این سه رمان نویس بزرگ دوره ی ویکتوریا بپردازد. فرضیه ی اولیه ی تحقیق این بوده است که چارلز دیکنز (1870- 1812) با زبانی شوخ و گزنده، جورج الیوت(1880- 1819) با نگاهی آموزشی–اندرزگونه و توماس هاردی(1928- 1840) با رویکردی تلخ وانتقادی به...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1986
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.6.2.539